Detalhe da pesquisa
1.
Pathological α-syn aggregation is mediated by glycosphingolipid chain length and the physiological state of α-syn in vivo.
Proc Natl Acad Sci U S A
; 118(50)2021 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34893541
2.
Detection of neuron-derived pathological α-synuclein in blood.
Brain
; 145(9): 3058-3071, 2022 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35722765
3.
Cancer-type organic anion transporting polypeptide 1B3 (Ct-OATP1B3) is localized in lysosomes and mediates resistance against kinase inhibitors.
Mol Pharmacol
; 2022 Sep 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36167426
4.
Interaction of Alpha Synuclein and Microtubule Organization Is Linked to Impaired Neuritic Integrity in Parkinson's Patient-Derived Neuronal Cells.
Int J Mol Sci
; 23(3)2022 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35163733
5.
Computational decomposition reveals reshaping of the SARS-CoV-2-ACE2 interface among viral variants expressing the N501Y mutation.
J Cell Biochem
; 122(12): 1863-1872, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34516024
6.
Toxic Metamorphosis-How Changes from Lysosomal to Cytosolic pH Modify the Alpha-Synuclein Aggregation Pattern.
Biomacromolecules
; 21(12): 4673-4684, 2020 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32986422
7.
Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells.
J Immunol
; 201(10): 3106-3118, 2018 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30355783
8.
Modeling neuronopathic storage diseases with patient-derived culture systems.
Neurobiol Dis
; 127: 147-162, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30790616
9.
α-Synuclein in Parkinson's disease: causal or bystander?
J Neural Transm (Vienna)
; 126(7): 815-840, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31240402
10.
Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36.
Nature
; 504(7478): 172-6, 2013 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-24162852
11.
α-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models.
Proc Natl Acad Sci U S A
; 113(7): 1931-6, 2016 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26839413
12.
Characterization of the complex formed by ß-glucocerebrosidase and the lysosomal integral membrane protein type-2.
Proc Natl Acad Sci U S A
; 113(14): 3791-6, 2016 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27001828
13.
Functional Characterization of Colon Cancer-Associated Mutations in ADAM17: Modifications in the Pro-Domain Interfere with Trafficking and Maturation.
Int J Mol Sci
; 20(9)2019 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31060243
14.
The shedding protease ADAM17: Physiology and pathophysiology.
Biochim Biophys Acta Mol Cell Res
; 1864(11 Pt B): 2059-2070, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28705384
15.
Mannose 6-phosphate-independent Lysosomal Sorting of LIMP-2.
Traffic
; 16(10): 1127-36, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26219725
16.
Activation of ß-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons.
J Neurosci
; 36(29): 7693-706, 2016 07 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27445146
17.
LIMP-2 expression is critical for ß-glucocerebrosidase activity and α-synuclein clearance.
Proc Natl Acad Sci U S A
; 111(43): 15573-8, 2014 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-25316793
18.
Calcium negatively regulates meprin ß activity and attenuates substrate cleavage.
FASEB J
; 29(8): 3549-57, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25957281
19.
Lysosomal integral membrane protein type-2 (LIMP-2/SCARB2) is a substrate of cathepsin-F, a cysteine protease mutated in type-B-Kufs-disease.
Biochem Biophys Res Commun
; 457(3): 334-40, 2015 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25576872
20.
Action myoclonus-renal failure syndrome: diagnostic applications of activity-based probes and lipid analysis.
J Lipid Res
; 55(1): 138-45, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24212238